Anti-Bcl-6
B-cell lymphoma 6 protein (BCL6) is a zinc finger transcriptional repressor encoded by the BCL6 gene located on chromosome 3q27. It plays a critical role in the formation and maintenance of germinal centers by regulating B-cell proliferation, differentiation, apoptosis, and DNA damage responses. BCL6 is predominantly expressed in germinal center B lymphocytes and T follicular helper cells and is involved in lymphocyte activation and maturation. Aberrant expression and chromosomal rearrangements involving BCL6 are frequently observed in B-cell non-Hodgkin lymphomas, particularly diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma, making BCL6 an important diagnostic, prognostic, and immunephenotypic marker in hematopathology.
| Regulatory Claim | RUO |
|---|---|
| Clone | BCL6/1982 |
| Localisation | Nucleus |
| Pack | 6 mL – Manual – RTU, 100 Tests – Automation – i6000, 50 tests – NanoVIP, 50 Tests – Automation – Xmatrx, 160 Tests – Automation – Xmatrx, 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate |
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