BCl-2 (B-cell lymphoma 2), encoded in humans by the BCl-2 gene, is the founding member of the BCl-2 family of regulator proteins that regulate cell death, by either inducing it (pro-apoptotic) or inhibiting it (anti-apoptotic). BCl-2 is specifically considered as an important anti-apoptotic protein and is thus classified as an oncogene. BCL-2 alpha expression inhibits the programmed cell death (apoptosis). BCL-2 protein express levels increases in most follicular lymphomas, neoplastic germinal centers, whereas the normal or hyperplastic germinal centers are negative. Bcl-2 marker is significant in differentiating follicular lymphoma from reactive follicular proliferation (bcl-2 negative). In addition, bcl-2 has been shown to be correlated with disease prognosis in breast cancer, prostate cancer, ovarian?cancer.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | SP66 |
| Source | Rabbit |
| Tissue Type/Cancer Type | Tonsil |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
