Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activity of Bcl-2. It recognizes a protein of 21kDa, identified as the Bax protein. This shows no cross-reaction with Bcl-2 or Bcl-X protein. Bax has extensive amino acid homology with Bcl-2 and it homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | 2D2 |
| Source | Mouse |
| Tissue Type/Cancer Type | Hodgkin?s Lymphoma |
| Pack | 6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides ? Xmatrx, 5 slides ? Manual |
