bFGF is a pro-angiogenic cytokine which is present in diverse tissues. It is known to function as an autocrine mediator of mitogenesis of endothelial cells in vivo, resulting in angiogenesis. It also increases fibroblast production of plasminogen activator and collagenase. bFGF is a heparin binding cytokine that is found inside cells and in extracellular stores bound to heparin or heparin sulfate proteoglycans. bFGF may be released to mediate tissue repair since its expression is known to be high in mast cells responding to injury. The monoclonal antibody to bFGF can be used for the study of myometrial smooth muscle cells, uterine leiomyomas, cardiac myocytes, arterial endothelium, gastric carcinoma, and invasive or metastatic melanoma.
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