BAP1 (BRCA1-Associated Protein 1) is an 80 kDa deubiquitinating enzyme that belongs to the ubiquitin C-terminal hydrolase (UCH) family of deubiquitin enzymes (DUBs). It is involved in the removal of ubiquitin from proteins and helps in regulate diverse cellular processes such as transcription, DNA-damage response, cell cycle progression, chromatin dynamics and DNA synthesis. Additionally, BAP1 can function both as tumor suppressor and metastasis suppressor. Mutations in BAP1 have been identified in aggressive mesotheliomas, uveal melanoma and cutaneous melanoma, clear cell renal cell carcinoma and bladder tumours.
Intended Use: IVD
Antibody Type: Nucleus and Cytoplasm
Clone: BAP1/8959R
Source: Rabbit
Tissue Type/Cancer Type: Breast carcinoma, malignant mesothelioma tissues