BLA.36 is a developmentally regulated 36 kDa antigen expressed on the plasma membrane of B lymphocytes, Reed-Sternberg, and mononuclear Hodgkin’s cells. The anti-BLA.36 antibody recognizes all four subtypes of Hodgkin’s disease. It also gives strong staining of B cell lymphomas including follicular center cell lymphomas (large and small cell types), mantle zone lymphomas, and immunoblastic lymphomas. No reactivity of anti-BLA.36 is found in normal epithelial cells, including adrenal gland, breast, colon, lung, salivary gland, skin, stomach and their malignant counterparts. Anti-BLA.36 can be used to distinguish Reed-Sternberg cells and some B-cell lymphomas from other malignant cells.
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