Aurora B is a 39kDa serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC) required for chromosome alignment/segregation during mitotic and meiosis events. Aurora B forms a complex with nonenzymatic subunits of CPC known as the inner centromere protein (INCENP), survivin and borealin. These complexes play a critical role in accurate chromosome alignment and segregation, histone modification, protein localization to the centromere and kinetochore, cytokinesis, proper microtubulekinetochore attachment and regulation of the mitotic check point. Aurora B is overexpressed in a variety of human tumors including non-small cell lung carcinoma, seminoma, astrocytoma and carcinomas of the colon, breast, prostate, endometrium and thyroid.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | AURKB/1521 |
| Source | Mouse |
| Tissue Type/Cancer Type | Tonsil, Placenta, Hodgkin’s, Lymphoma, colon and colon carcinoma tissue |
| Pack | 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
