DatasheetSDS

Arginase 1 (also known as liver type arginase or Type 1 arginase, ARG1) is a 35-40 kDa member of the arginase family of enzymes that catalyzes the breakdown of L-arginine into ornithine and urea. It demonstrates two distinct functions: it catalyzes the conversion of arginine to ornithine and urea in the hepatocyte cytoplasm, while in multiple cells, it degrades arginine, thus indirectly downregulating Nitric Oxide synthase activity by depriving this enzyme of its substrate. It is a highly expressed cytosolic enzyme in the liver and other tissues, including the brain. Arginase 1 also appears to play critical roles throughout the CNS for survival and regeneration of neurons and axons. Arginase 1 is an excellent marker for hepatocytes and used in differential diagnosis of Hepatocellular carcinoma from metastatic tumors of the liver.