DatasheetSDS

There are two forms of interleukin-1 exists and designated as IL1? and IL-1?. Interleukin 1? (IL-1?) and IL-1? are equally potent inflammatory cytokines that activate the inflammatory process, and their deregulated signaling causes devastating diseases manifested by severe acute or chronic inflammation.Although much attention has been given to understanding the biogenesis of IL-1?, the biogenesis of IL-1? and its distinctive role in the inflammatory process remain poorly defined. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.