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Alpha-1 antitrypsin (α1AT or AAT) is a 54kDa glycoprotein largely produced in the liver. It is a serine protease inhibitor and balances the action of neutrophil-protease enzymes in the lungs. It is useful in identifying benign and malignant hepatic tumors and yolk sac carcinomas. AAT expression is also used in detection of benign and malignant lesions of histiocytic nature. It is considered to be a useful tool in the screening of patients with cryptogenic cirrhosis or other forms of liver disease with fibrosis of uncertain origin.