DatasheetSDS

ALK Antibody also designated CD246 antibody, ALK RTK antibody, or type 1 receptor tyrosine kinase ALK antibody. This antibody recognizes a formalin-resistant epitope in both the 80 kDa NPM-ALK chimeric and the 200 kDa normal human ALK proteins. The wild-type anaplastic lymphoma kinase (ALK) protein expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes). The hybrid gene, NPM-ALK, formed by the chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), adhered to the cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. ALK plays a major in development of brain and can effect specific neurons in nervous system. Recent study shows that the NPM-ALK fusion gene is oncogenic. A truncated form containing the catalytic domain of ALK is expressed as the result of a translocation occurring in many nonHodgkin?s lymphomas. ALK Antibody stains cytoplasm and nuclear in t(2;5)-positive cells. This antibody helps in the identifying anaplastic large cell lymphoma (ALCL) and also used in a panel with CD15, CD30, TIA-1 and EMA