ALDH1A1 (aldehyde dehydrogenase family 1 member A1), also designated as retinal dehydrogenase 1 (RalDH1 or RALDH1), is a liver cytosolic isoform of acetaldehyde dehydrogenase belongs to the aldehyde dehydrogenase family of proteins. It is involved in alcohol metabolism pathway and also essential for conversion of retinol to retinoic acid which is very important in cell to cell signaling. ALDH1A1 is predominantly expressed in epithelium of testis, brain, liver, eye, kidney as well as neural and hematopoietic stem cells. It plays a critical role in multiple biological activities including drug resistance, cell differentiation and oxidative stress response. High expression of ALDH1A1 is found in solitary fibrous tumor (SFT), Hemangiopericytoma (HPC), melanoma, lung cancer and glioblastoma.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: rALDH1A1/7285
Source: Mouse
Tissue Type/Cancer Type: Testis, Colon, Lung, Testicular carcinoma tissue