DatasheetSDS

Adrenocorticotropic hormone (ACTH or Corticotropin) is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with corticotrophin-releasing hormone from the hypothalamus). Its principal effects are increased production of androgens and as its name suggests, cortisol from the adrenal cortex. Ab-1 is excellent for staining of routine formalin-fixed, paraffin-embedded tissues. It labels corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas