ACE2 (Angiotensin Converting Enzyme 2) is a type I integral transmembrane zinc metalloprotease belongs to the ACE family. It is a critical component in the rennin-angiotensin system (RAS) and catalyzes the conversion of inactive vasoconstrictor angiotensin I to Ang1-9 or of angiotensin II to the vasodilator angiotensin 1-7. ACE2 plays a essential role in regulation of cardiovascular, renal functions and serves as a functional receptor for spike glycoprotein of SARS coronaviruses. The expression of ACE2 is found in vascular endothelial cells of the heart and kidney and Leydig and Sertoli cells of the testis.
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