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Anti-Aberrant Endothelial Cell

SKU: AM382GP Categories: , , ,
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Product Description

In an in vivo model of allergic contact dermatitis, 4A11 antigen was differentially upregulated from other endothelial markers such as E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1. Monoclonal antibody 4A11 reacts with the H-5-2 and Lewis Y-6 blood group glycolipids. The expression of the novel 4A11 antigen in inflamed and malignant tissues, its differential upregulation in allergic contact dermatitis may signify an important function for this antigen in the inflammatory process. This antibody reacts with vascular endothelial cells in lymphoid tissues and endothelial cells in diseased tissue such as rheumatoid and osteoarthritic synovium, psoriatic skin, adrenal tumors and cutaneous Kaposi?s sarcomas. It does not react with several myeloid or lymphoid cell lines, peripheral blood cells and platelets. It does not detect endothelium of medium-sized vessels and that of normal tissues such as liver and spleen.

Intended Use

IVD

Antibody Type

Monoclonal

Clone

4A11

Source

Mouse

Tissue Type/Cancer Type

Tonsil

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual