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Immunohistochemistry

Overview of Immunohistochemistry

Diagnostic pathology has exponentially advanced over the last few decades due to the implementation of various novel techniques. The most notable of these techniques for diagnosis is immunohistochemistry (IHC). BioGenex, a pioneer in molecular pathology solutions and precision medicine, has been serving the diagnostic community for over 30 years and has been known for the continued development of innovative IHC products.

What is Immunohistochemistry?

Immunohistochemistry is a well-established, highly specific and sensitive method that allows the localization of an antigen within a cell or any other biological tissue samples with high resolution. The bound antigen-antibody complexes are then visualized using chemically linked enzymes, dyes, or fluorescent labels.  The method combines molecular detection with morphological features and can be used on formalin-fixed paraffin-embedded (FFPE) tissue sections, frozen tissue sections, and any other cytological preparations. IHC is also used for differential diagnoses, a limitation for conventional hematoxylin and eosin analysis. The breakthrough developments of a) monoclonal antibodies, b) antigen exposure technique in preserved tissues, c) sensitive visualization methods, and d) automated strainers have made IHC an indispensable tool for modern molecular diagnostic laboratories.