EGFR (Pan)

Catalog Number
  • NU473-UCE (1 mL)
  • AN473-5ME (6 mL)
  • AN473-10ME (10 mL)
  • AX473-YCDE (16 mL)

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Epidermal growth factor receptor (EGFR) is a 170-kDa transmembrane glycoprotein receptor found on a variety of cell types. After a ligand binds to a single-chain EGFR, the receptor forms a dimer that signals within the cell by activating receptor autophosphorylation through tyrosine kinase activity. Autophosphorylation triggers a series of intracellular pathways that may result in ion transport, morphological changes and proliferative activity. The antibody detects both EGFR phosphorylated on Tyrosine 1068 of the mature human isoform 1 (corresponding to Y1092 from the precursor form P00533-1/p170), and also unphosphorylated EGFR.