Thyroid transcription factor 1 (TTF-1) is a homeodomain-containing transcription factor that regulates the expression of thyroid and lung-specific genes. TTF-1 is detected in small cell carcinomas, neuroendocrine carcinomas, and thyroid carcinomas. As such, TTF-1 can help identify primary pulmonary carcinomas and differentiate it from metastatic carcinomas. Keratins are intermediate filaments f...
DOG1 is a cell surface protein selectively expressed in gastrointestinal stromal tumors (GIST). The DOG1 protein shows no homology at the DNA or amino acid level with KIT. DOG1 antibody labels the epithelium of the following organs: breast, prostate, salivary gland, liver, stomach, testis, pancreas, and gallbladder. DOG1 is a useful marker for GISTs, including PDGFRA mutants that fail to expres...
Skin tissue stained with Cytokeratin cocktail AE1 & AE3 using AEC chromogen
Human cytokeratins (40 kD to 68 kD) are a family of water-insoluble proteins that form a major part of the cytoskeleton of epithelial cells. Immunohistochemical analysis of a large variety of neoplasms has established keratin protein immunohistochemistry as an important aid for classification of epithelial neoplasms. Monoclonal antibodies AE1 and AE3 recognize the acidic and basic subfamilies o...
Colon Carcinoma stained with anti-Mucin-2 using AEC Chromogen
Mucins are a group of high molecular weight, highly glycosylated proteins expressed in normal and carcinogenic colon. MUC-2 is a 520-kD glycoprotein of the gastrointestinal tract. The core of the glycoprotein consists of a variable number of tandem repeats of a 23 amino acid sequence. Mucin-2 is found in normal epithelial cells of the colon or in colon carcinoma. Muc-2 glycoprotein is expressed in...
